Chronic Recurrent Multifocal Osteomyelitis (CRMO)

Overview

Chronic Recurrent Multifocal Osteomyelitis, or CRMO for short, is a rare condition where bones get inflamed and painful. It mostly happens in kids and teens. In this condition, the pain and inflammation keep coming back and can affect many bones in the body. Unlike some bone issues, CRMO isn’t caused by an infection. Instead, it’s caused by the immune system not working quite right.

Symptoms

Common symptoms of CRMO include:

  • Bone pain: Persistent or recurring pain in one or more bones.
  • Swelling: Swelling or tenderness around the affected bones.
  • Fever: Episodes of fever without a clear infection.
  • Fatigue: Feeling unusually tired or weak.
  • Limited movement: Reduced ability to move the affected limbs or joints.

Causes

The exact cause of CRMO is not known, but it is thought to be related to an abnormal immune response. Some possible factors include:

  • Immune system malfunction: The body’s immune system mistakenly attacks healthy bone tissue.
  • Genetic factors: There may be a genetic predisposition that increases the risk of developing CRMO.
  • Inflammatory triggers: Certain environmental factors or infections might trigger the condition in susceptible individuals.

Diagnosis

Diagnosing CRMO can be challenging due to its symptoms being similar to other conditions. The process typically involves:

  • Medical history and physical examination: Reviewing symptoms and assessing bone pain and swelling.
  • Imaging tests: Such as X-rays, MRI, or bone scans to identify inflammation and damage in the bones.
  • Blood tests: To check for markers of inflammation and rule out infections or other conditions.
  • Bone biopsy: In some cases, a biopsy may be performed to examine the bone tissue and confirm the diagnosis.

Treatment Options

Managing CRMO involves a combination of treatments aimed at reducing inflammation, controlling pain, and improving quality of life. At Gertrude’s Children’s Hospital, we offer:

  • Medications: Including nonsteroidal anti-inflammatory drugs (NSAIDs) and other medications to reduce inflammation and manage pain.
  • Biologic therapies: Advanced treatments that target specific parts of the immune system to reduce inflammation.
  • Physical therapy: To help maintain movement and strength in affected areas.
  • Lifestyle adjustments: Recommendations for managing symptoms and preventing flare-ups.

Patient Success Stories

At Gertrude’s Children’s Hospital, we are committed to providing the best possible care for children with Chronic Recurrent Multifocal Osteomyelitis (CRMO). Here’s why families trust us:

“Dealing with CRMO was challenging for our family, but the team at Gertrude's Children's Hospital was incredibly supportive. Their expertise and personalized care made a significant difference in managing our child's symptoms and improving their quality of life.”

Lisamother of a patient with CRMO

Chronic Recurrent Multifocal Osteomyelitis (CRMO)

CRMO is a chronic condition, which means it can last for years and may have periods of flare-ups and remission. Treatment aims to manage symptoms and improve quality of life.

Currently, there is no cure for CRMO, but with proper treatment, many people can manage their symptoms effectively and lead active lives.

If you notice persistent bone pain or swelling in your child, contact us for an evaluation. Early diagnosis and treatment are important for managing symptoms and preventing complications.

Contact Us

If your child is experiencing symptoms of CRMO or you have concerns about their bone health, please reach out to us to schedule an appointment. Our expert team is here to provide the best care for your child.

Contact us today to learn more about our Chronic Recurrent Multifocal Osteomyelitis (CRMO) treatment options.

Book Appointment