Apnea of Prematurity in Children

Overview

Apnea of prematurity occurs when a premature baby (born before 37 weeks) experiences breathing pauses that last more than 20 seconds. Sometimes, the pauses can be shorter but still cause the baby’s heart rate to drop below 100 beats per minute, or lead to a bluish skin color (central cyanosis) or low oxygen levels (below 85%).

The main cause is that the baby’s brain and nervous system, which control breathing, are not fully developed yet (central apnea). In some cases, if the breathing pause is long, there might also be some blockage in the airway.

About 25% of premature babies experience apnea of prematurity. This usually starts 2 to 3 days after they are born and rarely occurs on the first day.

The risk of apnea of prematurity is higher in babies born at an earlier gestational age (born earlier than expected).

The good news is that most premature babies outgrow apnea by the time they reach 37 weeks of corrected age (weeks since conception) and almost all by 44 weeks. The prognosis is excellent, meaning the condition typically resolves on its own as the baby matures.

Symptoms

The symptoms of apnea of prematurity can vary, but they generally include:

  • Pauses in Breathing: These pauses last more than 20 seconds.
  • Bradycardia: A drop in the baby’s heart rate, often accompanying a pause in breathing.
  • Cyanosis: A bluish color around the lips, fingers, or toes due to lack of oxygen.
  • Floppiness: The baby may seem less responsive or have reduced muscle tone during an apnea episode.

Causes

Apnea of prematurity happens because a baby’s respiratory system isn’t fully developed yet. This can affect how their brain and body control breathing.

There are three types of apnea in premature babies:

  • Central Apnea (Most Common): 
    • This is the most common type and occurs when the brain’s breathing control centers, which are still immature, don’t send the right signals to keep breathing regularly. 
    • The exact cause isn’t fully understood, but it involves the baby’s body not responding normally to low oxygen or high carbon dioxide levels.
  • Obstructive Apnea: 
    • This type happens when something blocks the baby’s airflow, making it hard to breathe. 
    • It can be caused by the baby’s neck being bent in a way that blocks the airway, nasal blockage, or a reflex that causes the vocal cords to close.
  • Mixed Apnea: 
    • Sometimes, a baby can have a combination of both central and obstructive apnea. 
    • This means that both the brain’s control of breathing and airflow obstruction are involved.

Diagnosis

Diagnosing apnea of prematurity typically involves monitoring the baby’s breathing, heart rate, and oxygen levels. Here’s how the diagnosis process works:

  • Monitoring and Evaluation: 
    • Babies with apnea of prematurity are closely monitored using cardiorespiratory monitors that track their breathing, heart rate, and oxygen levels. 
    • Diagnosis often involves observing these readings.
  • Ruling Out Other Causes: 
    • While apnea is often due to the baby’s immature breathing control, it can also be a sign of other issues like infections, low blood sugar, bleeding in the brain, or problems with the heart or nervous system. 
    • Doctors will thoroughly check for these other causes with a detailed history, physical examination, and necessary tests before concluding that the apnea is due to prematurity.

Treatment Options

Treatment for apnea of prematurity focuses on supporting the baby’s breathing and helping them grow out of the condition. Gertrude’s Children’s Hospital offers a range of treatment options, including:

  • Monitoring and Stimulation: 
    • Babies with apnea of prematurity are admitted to a monitored setting. 
    • If an apnea episode occurs, either noticed by caregivers or triggered by an alarm, gentle stimulation (like rubbing the baby’s back or feet) is often enough to restart breathing. 
    • If the baby doesn’t start breathing again, a bag-valve-mask is used to help them breathe.
  • Evaluating and Treating Underlying Causes: 
    • If the apnea episodes are frequent or severe, doctors will quickly check for any underlying issues, like infections, that can be treated. 
    • If no other cause is found, treatment focuses on supporting the baby’s breathing.
  • Respiratory Stimulants: 
    • For frequent or severe apnea, doctors may use medication which helps stimulate the baby’s breathing. 
  • Continuous Positive Airway Pressure (CPAP): 
    • If apnea persists despite using medication, the baby might be placed on CPAP, which provides gentle air pressure to keep the airways open and support breathing.
  • Ventilator Support: 
    • In rare cases where apnea is severe and doesn’t respond to other treatments, the baby may need a ventilator to assist with breathing.
  • Discharge and Monitoring: 
    • Before going home, doctors will monitor the baby to ensure they’ve gone 5 to 10 days without needing intervention for apnea. 
    • Some doctors might discharge the baby while still on medication if it’s working well, while others prefer to observe the baby in the hospital for a few more days after stopping treatment to make sure the apnea doesn’t come back.

Preventing Apnea of Prematurity: What You Need to Know

Home Monitoring:

  • When Can Your Baby Go Home Without a Monitor? 
    • If your baby has been in the hospital and hasn’t had any significant breathing or heart problems for 3 to 10 days, they can usually go home safely without a monitor.
  • When Might a Monitor Be Used at Home? 
    • Sometimes, if your baby is almost ready to go home but still has occasional breathing or heart issues that resolve on their own, a doctor might prescribe a home monitor or medication to help shorten their hospital stay. 
    • However, only a few babies are sent home with a monitor, and only if their episodes stop on their own without needing any intervention.
  • Parental Training: 
    • If your baby goes home with a monitor, you’ll be taught how to use the equipment, what to do if an alarm goes off, and how to perform CPR if necessary.
    • You’ll also be given 24/7 phone support and regular check-ins to help decide when to stop using the monitor. 
    • Monitors that can store event data are preferred.

Safe Sleep Positioning:

  • Back Sleeping Is Best: 
    • Always place your baby on their back to sleep on a firm, flat, and non-inclined surface, unless your doctor advises otherwise due to specific medical conditions. 
    • Avoid side sleeping or propping up the baby, as these positions are unstable.
  • Proper Head and Neck Position: 
    • Keep your baby’s head in the middle and their neck in a neutral or slightly extended position to prevent airway blockage.

Car Seat Safety:

  • Car Seat Challenge Test: 
    • All preterm infants, especially those with apnea of prematurity, should undergo a car seat challenge test before going home. 
    • This test ensures that your baby can maintain normal breathing, heart rate, and oxygen levels while in a car seat, reducing the risk of apnea, bradycardia, or low oxygen levels during car rides.

Patient Success Stories

At Gertrude’s Children’s Hospital, we are committed to providing the best possible care for children with Apnea of Prematurity. Here’s why families trust us:

“Our baby was diagnosed with Apnea of Prematurity, and we were so worried about their health. But the team at Gertrude's Children's Hospital was amazing. They explained everything to us and provided the best possible care for our baby.”

Sarahparent of a baby with apnea of prematurity

Apnea of Prematurity in Children

Apnea of prematurity is mainly caused by the immaturity of the baby’s respiratory system, which is common in babies born before 34 weeks. The brain may not yet be fully developed to regulate breathing consistently, leading to pauses.

While apnea of prematurity can be concerning, most cases are not life-threatening and improve as the baby matures. However, close monitoring and appropriate treatment are essential to manage the condition safely.

The duration of apnea of prematurity varies from baby to baby. Most infants outgrow the condition by the time they reach 36 to 40 weeks of gestation, though some may need monitoring and treatment for a longer period.

Most babies who experience apnea of prematurity do not have long-term issues. However, it’s important to follow up with your healthcare provider to ensure your baby’s respiratory system develops normally.

Treatment includes monitoring, gentle stimulation, positioning, CPAP, medications like caffeine, and in some cases, supplemental oxygen. The goal is to support the baby until they grow out of the condition.

If your baby has been discharged and experiences an apnea episode at home, gently stimulate them by rubbing their back or feet. If the apnea persists or if your baby shows signs of distress (such as turning blue or becoming very floppy), seek medical help immediately.

Babies with apnea of prematurity may need to stay in the hospital until they have outgrown the condition and can maintain stable breathing without assistance. The healthcare team will determine the best time for discharge based on your baby’s progress.

Yes, breastfeeding is encouraged if possible. Breast milk provides essential nutrients and immune support that are particularly beneficial for premature babies. Our lactation consultants are available to help you with breastfeeding or expressing milk if your baby is unable to breastfeed directly.

Supporting your baby’s development involves staying informed, being involved in their care, and providing a calm and loving environment. Kangaroo care (skin-to-skin contact) is also highly beneficial for promoting bonding and stability in premature babies.

While apnea of prematurity is not the same as SIDS, both conditions involve breathing irregularities. Close monitoring and following safe sleep guidelines can help reduce the risk of both apnea episodes and SIDS.

Contact Us

If your baby has been diagnosed with apnea of prematurity or if you have concerns about your baby’s breathing, we encourage you to schedule an appointment with our neonatal specialists. Our team is here to provide the support and care your baby needs to thrive.

Contact us today to learn more about our Apnea of Prematurity in Children treatment options.

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